热搜: 食品  烟台  奶粉  保健品  海产品  周黑  黑窝点  黑作坊  全聚德  小龙虾 
 
当前位置: 首页 » 检测应用 » 分析应用 » 生命科学应用 » 正文

Food Res Int:益生菌发酵荔枝汁对小鼠的免疫调节功能和肠道菌群的影响

放大字体  缩小字体 发布日期:2020-06-19
核心提示:益生菌发酵荔枝汁对小鼠的免疫调节功能和肠道菌群的影响
   研究热点:
 
  这是首份关于发酵荔枝汁(fermented litchi,FL)对小鼠免疫调节功能和肠道菌群影响的报告
 
  用干酪乳杆菌发酵后,发酵荔枝汁的益生菌功效大幅提高。
 
  发酵荔枝汁明显有助于防止小鼠免疫力下降。
 
  发酵荔枝汁可以保护小鼠肠道,改善肠道菌群。
 
  在过去的二十年中,含有益生菌的新功能食品开发备受关注。在这项研究中,广东省农产品加工重点实验室的Jing Wen、Lan Ma和Lu Li等人的研发了益生菌荔枝汁,并评估了其对免疫调节功能和肠道菌群的影响。首先,用干酪乳杆菌(Lactobacillus casei)发酵荔枝汁,荔枝汁的总酚、总黄酮和胞外多糖含量有所上升。因此,研究了发酵荔枝汁对环磷酰胺诱导小鼠的免疫调节作用。
 
  结果表明,发酵荔枝汁可增强免疫器官指标(脾脏、胸腺)和抗氧化能力,改善细胞因子(IL-2、IL-6)和免疫球蛋白(IgA、IgG、SIgA)的分泌,并能保护肠道。最后,通过高通量测序分析了发酵荔枝汁对肠道菌群的影响。在门和属水平上分别研究了优势微生物相对丰度的变化。用发酵荔枝汁处理后,厚壁菌门以及粪杆菌(Faecalibaculum)属、乳酸菌(Lactobacillus)属和艾克曼菌(Akkermansia)属的相对丰度都显着增加。这些发现表明,益生菌发酵荔枝汁可以减轻小鼠的免疫功能障碍并改变肠道菌群结构,从而为改善宿主健康提供功潜在的功能性食品。
 
  Abstract
 
  Effects of probiotic litchi juice on immunomodulatory function and gut microbiota in mice
 
  Jing Wen, Lan Ma,Yujuan Xu, Jijun wu, Yuanshan Yu, Jian Peng, Daobang Tang, Bo Zou, Lu Li*
 
  Sericultural & Argi-Food Research Institute, Guangdong Academy of Agricultural Sciences Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs Guangdong Key Laboratory of Agricultural Products Processing, No. 133 Yiheng Street., Dongguanzhuang Road, Tianhe District, Guangzhou 510610, China
 
  Development new functional foods containing probiotics had gained much attention during the past two decades. In this study, probiotic litchi juice was developed, and its effects on immunomodulatory function and gut microbiota were evaluated. Firstly, the litchi juice was fermented with Lactobacillus casei, which increased total phenolic, total flavone, and exopolysaccharide contents of the litchi juice. Hence, the immunomodulatory influence of fermented litchi juice (FL) was investigated in cyclophosphamide-induced mice. The results showed that FL enhanced immune organs indexes (spleen, thymus) and antioxidant capacity, improved the secretions of cytokines (IL-2, IL-6) and immunoglobulins (IgA, IgG, SIgA), and protected the intestinal tract. Finally, the effect of FL on gut microbiota was analyzed by high-throughput sequencing analysis. The changes in the relative abundance of dominant microbe were investigated at phylum and genus levels, respectively. After treatment with FL, the relative abundance of Firmicutes phylum was dramatically increased, as well as the genera of Faecalibaculum, Lactobacillus, and Akkermansia. These findings indicated that probiotic litchi juice could alleviate immune dysfunction and modify gut microbiota structure of mice, which provide a potential functional food to improve the host health.
 
 
[ 检测应用搜索 ]  [ 加入收藏 ]  [ 告诉好友 ]  [ 打印本文 ]  [ 违规举报 ]  [ 关闭窗口 ]

 
0条 [查看全部]  相关评论

 
推荐图文
推荐检测应用
点击排行
  

鲁公网安备 37060202000213号