N-硬脂酰-L-苏式-神经鞘氨 N-Octadecanoyl-L-threo-sphingosine

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Cat. Number	H1843
Chemical Name	N-硬脂酰-L-苏式-神经鞘氨 N-Octadecanoyl-L-threo-sphingosine
Category	synthetic
Mol. Formula	C₃₆H₇₁NO₃
Mol. Weight	566
Qty 1	1mg
Appearance	solid
Application Notes	98+% TLC, GC,分析标准品
Synonym	N-C18:0-L-threo-Ceramide; N-Stearoyl-L-threo-sphingosine
Solubility	chloroform, ethanol, DMSO, DMF ( up to 5mg/ml)
Storage condition	-20°C
References	1. N. S. Radin, “Killing tumours by ceramide-induced apoptosis: a critique of available drugs” Biochemical Journal, Vol. 371 pp. 243-256, 2003 2. W. Jarvis et al. “Induction of Apoptosis and Potentiation of Ceramide-mediated Cytotoxicity by Sphingoid bases in Human Myeloid Leukemia Cells” The Journal of Biological Chemistry, Vol. 271 pp. 8275-8284, 1996 3. C. Chalfant et al. “Long Chain Ceramides Activate Protein Phosphatase-1 and Protein Phosphatase-2A Activation is Stereospecific and Regulated by Phosphatidic Acid” The Journal of Biological Chemistry, Vol. 274 pp. 20313-20317, 1999 4. S. Laulederkind et al. “Ceramide Induces Interleukin 6 Gene expression in Human Fibroblasts” The Journal of Experimental Medicine, Vol. 182 pp. 599-604, 1995 5. T. Ariga et al. “Role of sphingolipid-mediated cell death in neurodegenerative diseases” Journal of Lipid Research, Vol. 39 pp. 1-16, 1998