杂粮可调节肠道菌群结构。
杂粮物通过影响细胞周期停滞和凋亡来预防肿瘤。
杂粮可以通过阻断炎症信号传导来保护心血管系统。
配方先进的杂粮具有益生元功效。
杂粮（coarse cereals, CC）是指除大米和小麦以外的谷类，它们被高度评价为具有营养和药理特性的功能性食品。由于它们对慢性病具有多种积极作用，因此杂粮在食品工业中起着至关重要的作用。杂粮及其主要成分通过促进细胞凋亡、诱导细胞周期停滞以及调节转移起始来预防肿瘤发病。同时，杂粮可以通过影响多种通路来改善心血管疾病，例如CaMKII/p-BFAF-3、NF-κB、MAPK、PI3K/Akt等。此外，杂粮及其主要成分具有潜在的益生元作用，可促进双歧杆菌和乳杆菌等益生菌的活性和生长。
但是，有关杂粮有益特性的报道较少，其潜在机理尚未得到充分了解。成都大学医学院的Jia Fu、Yan Zhang和Liang Zou*以及成都中医药大学针灸推拿学院的Yong Tang*等人通过本文详细解释了杂粮对肿瘤、炎症和心血管疾病等慢性疾病的作用和机理。
Abstract
Concise review: Coarse cereals exert multiple beneficial effects on human health
JiaFua, YanZhanga, YichenHub, GangZhaob, YongTangc, LiangZoua
a School of Medicine, Chengdu University, No. 2025, Cheng Luo Road, Chengdu 610106, Sichuan, China
b Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Chengdu University, No. 2025, Cheng Luo Road, Chengdu 610106, Sichuan, China
c School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, No.1166, Liutai Avenue, Wenjiang District, Chengdu 611137, Sichuan, China
Coarse cereals (CC) refer to cereal grains except for rice and wheat which are highly-valued as functional foods with nutritional and pharmacological properties. Owing to their diverse positive effect on chronic diseases, coarse cereals exert a vital role in food industry. CC and the main contents prevent tumor pathogenesis through promoting apoptosis, inducing cell cycle arrest as well as modulating metastasis initiation. Meanwhile, CC ameliorates cardiovascular diseases through affecting multiple pathways, such as CaMKII/p-BFAF-3, NF-κB, MAPK, PI3K/Akt, etc. Besides, CC and the main contents have potential as prebiotics which facilitating the activities and growth of probiotics such as Bifidobacteria and Lactobacillus. However, there’s a lack of report on CC’ beneficial properties and the underlying mechanisms are not fully understood. Here this article explains in detail, the effect and mechanism of CC on chronic diseases like tumor, inflammation and cardiovascular diseases.
