结果表明，几种成分显着降低了镉在肠期中的溶解度（10％～98％）。单宁酸、TiO2、葡萄糖酸锌、CaCl2和原花青素对降低稻米中镉的生物可给性最有效，降低率分别达到93％～97％、54％～61％、32％～49％、24％～32％和11％～14％。添加膳食成分后，肾脏和肝脏中镉相对生物利用度（Cd-RBA）的降低率分别为20％～58％和10％～31％。该结果可能对降低因食用稻米而镉暴露产生的健康风险具有重要意义。
Use of Dietary Components to Reduce the Bioaccessibility and Bioavailability of Cadmium in Rice
Shuo Sun?,||, Xiaofang Zhou?, ||, Yingwen Li?, Yongxing Li?, Hanping Xia?, Zhian Li?,*, Ping Zhuang?,?,§,*
? South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, PR China
|| College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, PR China
? Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, PR China
§ Center for Plant Ecology, Core Botanical Gardens, Chinese Academy of Sciencecs, Guangzhou 510650, PR China
Abstract
Reducing Cd bioavailability in the systemic circulation is an alternative strategy to reduce Cd exposure. The influence of 39 dietary components on Cd bioaccessibility in water or rice was determined using an in vitro gastrointestinal model, following which an in vivo bioassay was used to determine the most effective components on Cd bioavailability in rice. The results showed that several components significantly reduced the solubility of Cd (10–98%) in the intestinal phase. Tannic acid, TiO2, zinc gluconate, CaCl2, and proanthocyanidins were the most effective in decreasing Cd bioaccessibility in rice, with reductions of 93–97, 54–61, 32–49, 24–32, and 11–14%, respectively. Upon adding the dietary components, the reduction rates of the Cd-relative bioavailability (Cd-RBA) were 20–58 and 10–31% in the kidneys and the liver, respectively. The results may have important implications for reducing health risks associated with Cd exposure via consumption of rice.
