*膳食油凝胶可减少大鼠体质量增加；
*高脂诱导的脂滴增大和肝脂肪变性面积的增加在油凝胶的处理下降低；
*在饮食中补充油凝胶有利于抑制脂肪生成和促进血管生成。
韩国世宗大学食品科学与生物技术系的Utthapon Issara、Suhyun Park、Suyong Lee等人旨在探讨油凝胶（oleogel）对高脂饮食大鼠脂质代谢的影响。雄性SD大鼠（n=32，4周龄）和肥胖Zucker大鼠（n=6）分别饲喂含牛脂（beef tallow）的高脂饲料（high fat diet，HFD）和含菜籽油的蜂蜡油凝胶（beeswax oleogel，BOG）2个月。
BOG替代50%BT后体质量显着降低。BOG可降低HFD引起的血清甘油三酯升高（P<0.05），膳食中BOG使血清HDL胆固醇升高（P<0.05）。BOG可降低HFD诱导的脂质面积增加和肝脂肪变性（P<0.05）。与HFD组相比，BOG组内脏脂肪中肉碱棕榈酰转移酶-1表达上调。BOG还可增加Zucker大鼠血管生成基因、血管内皮生长因子和一氧化氮合酶（P<0.05）。
这些结果表明，BOG能有效地减少肥胖大鼠的脂肪生成，促进血管生成。
Health functionality of dietary oleogel in rats fed high-fat diet: A possibility for fat replacement in foods
Utthapon Issaraa，Suhyun Parka，Suyong Leea，Jaehwan Leeb，Sungkwon Parka
aDepartment of Food Science and Biotechnology, Sejong University, Seoul, Republic of Korea
bDepartment of Food Science and Biotechnology, Sungkyunkwan University, Suwon, Republic of Korea
Abstract
This study was to determine the effect of oleogel on lipid metabolism in rats fed high-fat diet. Male SD rats (n = 32; 4-wk-old) and obese Zucker rats (n = 6) fed either beef tallow containing high fat diet (HFD) or beeswax oleogel containing canola oil (BOG) for 2 months. Substitution of 50% BT by BOG significantly reduced body weight. Increased serum triglyceride by HFD was reduced (P < 0.05) by BOG. Serum HDL cholesterol was increased (P < 0.05) by dietary BOG. HFD-induced increase in area of lipid and hepatic steatosis were decreased (P < 0.05) by BOG. Carnitine palmitoyltransferase-1 expression was upregulated in the visceral fat in BOG compare to HFD group. Angiogenesis genes, vascular endothelial growth factor and nitric oxide synthase, were also increased (P < 0.05) by BOG in Zucker rats. These results suggest that BOG effectively decreases adipogenesis and improves angiogenesis in obese rat model.
