利用细胞活力对Vero细胞系进行了抗单纯疱疹病毒1型（HSV-1）的抗病毒活性研究。只有两种植物提取物，即大戟科和桑科表现出有效的抗疱疹活性，其他6 种提取物显示出中度抑制作用。相比之下，通过生物测定对这两种植物进行植物化学探索，分离出纯类黄酮化合物。还检测了分离化合物的抗病毒活性，其中7种为纯化合物即： 没食子酸、山奈酚3-O-α-(6β-O-没食子酰基)-吡喃葡萄糖苷、槲皮素3-O-α-(6β-O-没食子酰基)吡喃葡萄糖苷、姜黄素、槲皮素和山奈酚表现出显着的抑制作用。
文章摘要/abstract
Antiviral effect of polyphenol rich plant extracts on
herpes simplex virus type 1
Sayed A. El-Toumya, Josline Y. Salib a,?, Walaa A. El-Kashak b, Christel Marty c, Gilles Bedouxc, Nathalie Bourgougnon c
（a. Chemistry of Tannins Department, National Research Centre, Dokki, 12622 Cairo, Egypt.
b. Chemistry of Natural Compounds Department, National Research Centre, Dokki, 12622 Cairo, Egypt.
c. Centre de Recherché et d’enseignement Yves Coppens, Campus de Tohannic, BP 573, 56017 Vannes, France）
Received 8 December 2016; received in revised form 23 August 2017; accepted 15 January 2018
Available online 15 February 2018
Abstract:
evaluation of the anti-herpetic activity of 25 Egyptian plants extracts was investigated in vitro in this study. The antiviral activity against Herpes Simplex Virus type 1 (HSV-1)was done onVero cell lines by cell viability. only two plants extracts; namely Euphorbia coopire (Euphorbiaceae) and Morus alba (Moraceae) showed potent anti-herpetic activity and six other extracts showed moderate inhibition. In contrast, a bioassay monitored phytochemical exploration of these two plants led to the isolation of pure flavonoid compounds. The antiviral activity of the isolated compoundswas also examined, among which seven pure compounds namely; 7-galloyl catechin, gallic acid, kaempferol 3-O--(6-O-galloyl)-glucopyranoside, quercetin 3-O--(6-O-galloyl)-glucopyranoside, curcumin, quercetin and kaempferol exhibited significant inhibition.
